Drug Interactions:Acitretin: May enhance the hepatotoxic effect of methotrexate. Hematologic: Methotrexate can suppress hematopoiesis and cause anemia, aplastic anemia, leukopenia, and or thrombocytopenia. Rheumatoid nodules may also increase in size during methotrexate therapy, despite good control of the disease process. To be sure this medication is not causing harmful effects, your blood will need to be tested on regular basis. Is induced abortion with methotrexate bon marche mexicain misoprostol risk factor for late term abortion or preterm delivery in subsequent pregnancies? European Journal of Obstetrics Gynecology and Reproductive Biology. In the case of early missed miscarriage particularly blighted ovum in which fetal demise has occurred but the body has not expelled the fetus, methotrexate may be used to help the body begin the miscarriage process.